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KMID : 0363420160300040077
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Journal of Korean Oriental Pediatrics
2016 Volume.30 No. 4 p.77 ~ p.86
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Anti-inflammatory Effects of Hataedock with Douchi in Atopic Dermatitis-like Skin Lesions in House Dust Mite-Induced NC/Nga Mice
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Ahn Sang-Hyun
Kim Ki-Bong
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Abstract
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Objectives: Hataedock (HTD) is an oral Korean herbal medical oral treatment that removes fetal toxic heat and meconium
from new born babies. The purpose of this study is to evaluate whether Hataedock treatment of Duchi extracts has anti-inflammation effects in atopic dermatitis-like skin lesions in House Dust Mite-Induced NC/Nga Mice.
Methods: The mice were divided into 3 groups (n=10 per group) as follows: the control group (Ctrl group), AD-induced
group (AE group), AD-induced with HTD treatment group (DT group). 3-week-old NC/Nga mice were introduced to Hataedock treatment, made of Duchi extract. After 4 weeks, House Dust Mite-Induced application was used six times per week for 3 weeks to induce the first atopic dermatitis, and second AD in 7 weeks after. To examine skin injuries and anti-inflammatory effect, PKC, MMP-9, iNOS immunohistochemistry were used.
Results: The alleviate effect of the skin damage and angiogenesis was observed in DT group. The damage of stratum
corneum, hyperplasia, edema, infiltration of lymphocytes and distribution of capillary were decreased in DT group. Also, the study results suggested that Hataedock treatment made of Duchi extracts in DT group remarkably decreased skin damages by 51% (p < 0.001), as well as PKC by 91%, MMP-9 by 48% (p < 0.001), iNOS by 51% (p < 0.001).
Conclusions: Based on the study results, we observed that Hataedock treatment of Duchi extracts alleviates AD by diminishing various inflammatory cytokines, initial steps of AD development, in the skin lesions. Potential applications for
prevention and treatment of atopic dermatitis are expected.
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KEYWORD
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Hataedock, Duchi, Atopic dermatitis, PKC, MMP-9, iNOS
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